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Traveling to Puno and other high-altitude locations in Peru, such as Machu Picchu, can be an exhilarating experience. However, it also comes with the risk of altitude sickness, especially for those who are not acclimated to high elevations. Puno, located at approximately 3,830 meters (12,570 feet), is one of the highest cities in the world. Visitors may begin to feel symptoms of altitude sickness within a few hours of arrival.

To mitigate the effects, it is advisable to take your time when ascending to higher elevations. Start with a few days in Cusco (3,400 meters or 11,155 feet) before heading to Puno. Staying hydrated is crucial; drink plenty of water and herbal teas like coca tea, which is believed to help alleviate symptoms.

It's also wise to avoid heavy meals, alcohol, and strenuous activities during your first days at high altitudes. If symptoms like headache, dizziness, or nausea persist, it’s essential to descend to lower elevations. Some travelers find that ginseng or ginger can help ease symptoms.

Additionally, consider using medications such as Acetazolamide (Diamox) as a preventative measure, but consult your doctor beforehand. Embrace the local culture by engaging with the Aymara and Quechua communities in Puno, as they have a wealth of knowledge about adapting to high-altitude living.

Remember that the vibrant festivals, such as the Festival of the Virgin of Candelaria, are worth experiencing, so plan your visit accordingly. Lastly, don't forget to enjoy the breathtaking views of Lake Titicaca and the unique floating islands.